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The effectiveness of medicines based on glipizide is significantly diminished with the concurrent intake of glucocorticoids, amphetamines, anticonvulsants, asparaginase, baclofen, calcium antagonists, carbonic anhydrase inhibitors, oral contraceptives, epinephrine, ethacrynic acid, furosemide, glucagon, salicylates, thiazide diuretics, thyroid hormones, and other medicines that contribute to the blood sugar rise.